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M9470134.TXT
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1994-07-02
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Document 0134
DOCN M9470134
TI Selenium in the maintenance and therapy of HIV-infected patients.
DT 9409
AU Schrauzer GN; Sacher J; University of California, San Diego, Department
of Chemistry and; Biochemistry, La Jolla 92093.
SO Chem Biol Interact. 1994 Jun;91(2-3):199-205. Unique Identifier :
AIDSLINE MED/94251846
AB Due to its antiviral effects and its importance for all immunological
functions, the administration of selenium is suggested as a supportive
measure in early as well as in advanced stages of HIV-induced disease.
Initial observations on the effects of selenium supplementation in
HIV-infected patients indicate that selenium causes symptomatic
improvements and possibly slows the course of the disease. As selenium
inhibits reverse transcriptase activity in RNA-virus-infected animals,
supplemental selenium could also prevent the replication of HIV and
retard the development of AIDS in newly HIV-infected subjects. An
adequate supply of selenium and of antioxidant vitamins is also proposed
as a measure to reduce the probability of the placental transmission of
HIV in pregnancy.
DE Acquired Immunodeficiency Syndrome/DRUG THERAPY
Antioxidants/THERAPEUTIC USE AIDS-Related Complex/DRUG THERAPY Female
Human HIV/*DRUG EFFECTS HIV Infections/*DRUG
THERAPY/IMMUNOLOGY/MICROBIOLOGY Male Pregnancy Pregnancy
Complications, Infectious/DRUG THERAPY Reverse
Transcriptase/ANTAGONISTS & INHIB Selenium/PHARMACOLOGY/*THERAPEUTIC
USE Vitamins/THERAPEUTIC USE JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).